From what I've seen so far, league play will be more competitive and entertaining than in the past several years.
Mitty, as always, is relentless and its depth gives it an edge. But VC has the size and strength to compete. SI is not quite as big, but it is highly athletic and already knocked off Pinewood. And St. Francis has a senior-laden team of athletes that has at least a puncher's chance against the others. I would watch any matchup among those four.
I don't see how Presentation wins a league game unless there are some transfers waiting in the wings. And while SHCP should beat Pres easily, it'll have a tough time stealing a win against the others.